Elucidating
Genetic Variation
to Power
Genomic Medicine 
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Our Mission

We are accelerating the development of life-saving precision diagnostics and therapeutics by elucidating the consequences of human genetic variation.

Our Edge

We specialize in integrating massively multiplexed functional genomics experiments with human biobank data using probabilistic machine learning.

Reach more patients through the power of genetics.

RareScan​ - Patient Expansion

More than half of people living with a rare disease remain undiagnosed and untreated.
Diagnoses are often complicated by variants of uncertain significance (VUS). Constantiam Biosciences’ RareScan™ platform uses Deep Mutational Scanning (DMS) to classify VUS and predict drug responses, improving patient access to treatments and aiding drug development for rare diseases.
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Genable - Target Discovery

Genable™ revolutionizes drug target discovery by using human genetic data, massively-multiplexed experiments, and machine learning to prioritize high-confidence targets.
This accelerates discovery, increases success rates, and reduces costs, offering a major advantage over traditional methods in developing precision diagnostics and therapies.
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StratiVar​ - Patient Stratification

StratiVar optimizes clinical trials enrollment by proactively assessing the susceptibility of all single amino acid variations of a targeted protein to a novel therapeutic.
These assessments are derived from drug-specific Deep Mutational Scans (DMS), centered on verified human data controls, and are translated into actionable insights including drug-sensitivity profile and predicted probabilities of patient response for clinical trial designers and physicians.
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MAVEvidence​ - VUS resolution

MAVEvidence is the premier functional evidence resource for the clinical genetics community.
MAVEvidence delivers increased productivity and time savings through comprehensive curation, rigorous analysis, and clear presentation of functional evidence derived from high-throughput studies of genetic variants.
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